Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 2/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747788 | 0.82 | THRB (0.33) | MAPT | |
| SCHEMBL6800909 | 0.80 | MAPT (0.32) | ALDH1A1MAPT | |
| SCHEMBL157410 | 0.74 | — | — | |
| SCHEMBL5691663 | 0.69 | — | — | |
| SCHEMBL1363669 | 0.69 | — | — | |
| SCHEMBL9300336 | 0.68 | SMN1; SMN2 (0.48) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL4651594 | 0.67 | CYP3A4 (0.40) | KDM4EALDH1A1TDP1 | |
| SCHEMBL6752334 | 0.67 | TNKS (0.36) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL6727052 | 0.67 | TNKS (0.36) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL20047225 | 0.65 | TLR4 (0.34) | ALDH1A1HTTHSD17B10POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-20220002769-A1 | ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-01-06 | — | — | US | disclosed |
| EP-1112269-A2 | HIV PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000015634-A2 | HIV PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-03-23 | — | — | WO | disclosed |
| EP-0214009-A2 | Enaminones as potential prodrugs of primary and secondary amines | MERCK & CO. INC. (US) | 1987-03-11 | — | — | EP | disclosed |