Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | PNLIP | P16233 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747788 | 0.85 | THRB (0.33) | MAPTTSHRCYP3A4THRBALOX15 | |
| SCHEMBL7361709 | 0.80 | KDM4E (0.36) | MAPTALDH1A1 | |
| SCHEMBL14041237 | 0.79 | — | — | |
| SCHEMBL157410 | 0.70 | — | — | |
| SCHEMBL18855283 | 0.66 | CYP3A4 (0.38) | CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL6602578 | 0.65 | CYP1A1 (0.52) | MAPTCYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL2217512 | 0.63 | THRB (0.41) | THRBALOX15SMN1; SMN2 | |
| SCHEMBL10326025 | 0.63 | THRB (0.41) | THRBALOX15SMN1; SMN2 | |
| SCHEMBL4651594 | 0.63 | CYP3A4 (0.40) | CYP3A4MAOAALDH1A1CYP1A2 | |
| SCHEMBL4446005 | 0.63 | THRB (0.41) | THRBALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134696-B1 | PROCESSES FOR THE PREPARATION OF STATINS, PARTICULARLY ROSUVASTATIN, AND INTERMEDIATES FOR THE PREPARATION THEREOF | LEK PHARMACEUTICALS (SI) | 2017-05-17 | — | — | EP | disclosed |
| US-8471045-B2 | Synthesis of statins | LEK PHARMACEUTICALS D.D. (SI) | 2013-06-25 | — | — | US | disclosed |
| US-20120196333-A1 | SYNTHESIS OF STATINS | LEK PHARMACEUTICALS D.D. (SI) | 2012-08-02 | — | — | US | disclosed |
| US-8183397-B2 | Synthesis of statins | LEK PHARMACEUTICALS D.D. (SI) | 2012-05-22 | — | — | US | disclosed |
| US-20110178295-A1 | SYNTHESIS OF STATINS | LEK PHARMACEUTICALS D.D. (SI) | 2011-07-21 | — | — | US | disclosed |
| WO-2008119810-A2 | PROCESSES FOR THE PREPARATION OF STATINS, PARTICULARLY ROSUVASTATIN, AND INTERMEDIATES FOR THE PREPARATION THEREOF | LEK PHARMACEUTICALS D.D. (SI) | 2008-10-09 | — | — | WO | disclosed |
| US-5670662-A | Pyranones | ZENECA LIMITED (GB) | 1997-09-23 | — | — | US | disclosed |
| US-5527916-A | Pyranones | ZENECA LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| US-5443971-A | Pyranones | ZENECA LIMITED (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0604525-A1 | ENZYMATIC PRODUCTION OF OPTICAL ISOMERS OF TETRAHYDROPYRAN-2-ONES | ZENECA LIMITED (GB) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993006236-A1 | ENZYMATIC PRODUCTION OF OPTICAL ISOMERS OF TETRAHYDROPYRAN-2-ONES | ZENECA LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178295-A1 | SYNTHESIS OF STATINS | HMGCR, DHCR7, COASY | MAPT 3576/4885TSHR 3984/4885CYP3A4 25/4885 |
| US-20120196333-A1 | SYNTHESIS OF STATINS | HMGCR, DHCR7, COASY | MAPT 3576/4885TSHR 3984/4885CYP3A4 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.