Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 3/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.37 |
| ▸ | METAP1 | P53582 | 2/20 | 0.37 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10354798 | 1.00 | SLC1A3 (0.37) | SLC1A3SLC1A2SLC1A1METAP1DPEP1 | |
| SCHEMBL10768614 | 1.00 | SLC1A3 (0.37) | SLC1A3SLC1A2SLC1A1METAP1DPEP1 | |
| SCHEMBL7440684 | 0.84 | REN (0.38) | METAP1METAP2ALOX5 | |
| SCHEMBL7440693 | 0.84 | REN (0.38) | METAP1METAP2ALOX5 | |
| Trifluoroacetic Acid SCHEMBL27759897 | 0.81 | GRIN2D (0.42) | SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B | |
| Trifluoroacetic Acid SCHEMBL3200966 | 0.81 | GRIN2D (0.42) | SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B | |
| SCHEMBL17789278 | 0.77 | METAP1 (0.40) | SLC1A3SLC1A2SLC1A1METAP1METAP2 | |
| SCHEMBL30415115 | 0.77 | METAP1 (0.40) | SLC1A3SLC1A2SLC1A1METAP1METAP2 | |
| SCHEMBL2652715 | 0.76 | GRIN2D (0.49) | SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B | |
| SCHEMBL123134 | 0.76 | GRIN2D (0.49) | SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0389535-A1 | RENIN INHIBITORS, PROCESSES FOR PREPARING THEM, METHODS FOR USING THEM, AND COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1990-10-03 | — | — | EP | disclosed |
| EP-0387309-A1 | RENIN INHIBITORS, PROCESS FOR PRODUCING THEM AND USE THEREOF | SANDOZ AG (CH) | 1990-09-19 | — | — | EP | disclosed |
| WO-1989010917-A2 | RENIN INHIBITORS, PROCESS FOR PRODUCING THEM AND USE THEREOF | SANDOZ AG (CH) | 1989-11-16 | — | — | WO | disclosed |
| WO-1989007610-A1 | RENIN INHIBITORS CONTAINING alpha-HETEROATOM AMINO ACIDS | WARNER-LAMBERT COMPANY (US) | 1989-08-24 | — | — | WO | disclosed |
| WO-1989003841-A1 | RENIN INHIBITORS, PROCESSES FOR PREPARING THEM, METHODS FOR USING THEM, AND COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1989-05-05 | — | — | WO | disclosed |
| WO-1989003820-A1 | BRANCHED BACKBONE RENIN INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0222523-A2 | Difluorocyclostatine containing polypeptides | PFIZER INC. (US) | 1987-05-20 | — | — | EP | disclosed |