Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.48 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350733 | 0.88 | GRIN2D (0.57) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL7354078 | 0.85 | SIRT2 (0.43) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL8609548 | 0.84 | CYP1A2 (0.57) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL7386120 | 0.84 | SIRT2 (0.42) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL7358401 | 0.83 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL9542780 | 0.82 | SIRT2 (0.52) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL7357748 | 0.81 | SIRT2 (0.48) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL7354092 | 0.80 | GRIN1 (0.42) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL7361295 | 0.79 | SIRT2 (0.46) | GRIA1GRIA2GRIA3GRIA4SIRT2 | |
| SCHEMBL9093775 | 0.79 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |