Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.42 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.42 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354618 | 0.97 | SIRT2 (0.46) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7357748 | 0.93 | SIRT2 (0.48) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7350733 | 0.86 | GRIN2D (0.57) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7353282 | 0.84 | SIRT2 (0.45) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7353289 | 0.83 | GRIK1 (0.40) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7355281 | 0.83 | GRIK1 (0.55) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7349770 | 0.81 | GRIK1 (0.61) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL9542780 | 0.81 | SIRT2 (0.52) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7361791 | 0.79 | GRIA1 (0.48) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7354370 | 0.79 | SRC (0.46) | SIRT2SIRT1GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993008173-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-29 | — | — | WO | claimed |
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| EP-0565683-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993008173-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-29 | — | — | WO | disclosed |