Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.44 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609548 | 0.89 | CYP1A2 (0.57) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7349770 | 0.85 | GRIK1 (0.61) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7357748 | 0.83 | SIRT2 (0.48) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7361791 | 0.82 | GRIA1 (0.48) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL9395642 | 0.82 | GRIA1 (0.57) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL31439102 | 0.82 | GRIA1 (0.57) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL31439101 | 0.82 | GRIA1 (0.57) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7355281 | 0.82 | GRIK1 (0.55) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7353360 | 0.81 | GRIK1 (0.59) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7353282 | 0.81 | SIRT2 (0.45) | SIRT2SIRT1GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993008173-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-29 | — | — | WO | disclosed |