Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | BLM | P54132 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | RECQL | P46063 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.46 |
| ▸ | THPO | P40225 | 3/20 | 0.46 |
| ▸ | MTOR | P42345 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20970239 | 0.82 | MMP9 (0.43) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL6420220 | 0.81 | TDP1 (0.46) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL28976212 | 0.80 | TDP1 (0.54) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL28976198 | 0.79 | LMNA (0.48) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL28976186 | 0.78 | KDM4E (0.56) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL4575928 | 0.78 | MMP9 (0.73) | TDP1KMT2AMMP9MEN1 | |
| SCHEMBL4996799 | 0.77 | LMNA (0.49) | TDP1MAPTLMNAMMP9ALOX12 | |
| Bromide SCHEMBL11805158 | 0.76 | TDP1 (0.52) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL13528632 | 0.76 | SMN1; SMN2 (0.57) | LMNAPOLBCYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28329790 | 0.75 | ACACB (0.49) | TDP1KDM4EMAPTLMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |