Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364894 | 0.87 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7365393 | 0.87 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CLMNA | |
| SCHEMBL7362076 | 0.80 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL8308698 | 0.78 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7369665 | 0.74 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL8308651 | 0.74 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7360454 | 0.71 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7364896 | 0.70 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7363892 | 0.69 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7363454 | 0.68 | PDE4A (0.74) | PDE4APDE4DPDE4BPDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |