Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.39 |
| ▸ | HRH1 | P35367 | 7/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362080 | 0.87 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7369665 | 0.86 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL8308698 | 0.82 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL8308651 | 0.80 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7362076 | 0.78 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7365393 | 0.74 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CLMNA | |
| SCHEMBL7370084 | 0.73 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7360454 | 0.72 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7364896 | 0.72 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7370144 | 0.71 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |