Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | LITAF | Q99732 | 2/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364894 | 0.80 | PDE4A (0.57) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL8308698 | 0.78 | PDE4A (0.57) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7370138 | 0.78 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL16535883 | 0.77 | PDE4A (0.44) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7363890 | 0.76 | PDE4A (0.61) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7359405 | 0.76 | PDE4A (0.61) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7363454 | 0.76 | PDE4A (0.74) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7370081 | 0.76 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7370144 | 0.76 | PDE4A (0.65) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9376018 | 0.76 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |