Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.61 |
| ▸ | METAP1 | P53582 | 7/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7361849 | 0.99 | METAP2 (0.60) | METAP2METAP1USP2CYP1A2CYP2C9 | |
| SCHEMBL7355924 | 0.80 | METAP2 (0.60) | METAP2METAP1USP2POLBKMT2A | |
| Hydrochloric Acid SCHEMBL7355919 | 0.79 | METAP2 (0.59) | METAP2METAP1POLBKMT2A | |
| SCHEMBL7354275 | 0.78 | METAP2 (0.63) | METAP2METAP1 | |
| SCHEMBL7362423 | 0.78 | METAP2 (0.63) | METAP2METAP1KMT2A | |
| SCHEMBL7356888 | 0.77 | METAP2 (0.69) | METAP2METAP1KMT2A | |
| SCHEMBL7351848 | 0.77 | METAP2 (0.69) | METAP2METAP1POLB | |
| SCHEMBL7351333 | 0.77 | METAP2 (0.69) | METAP2METAP1POLB | |
| Hydrochloric Acid SCHEMBL7352923 | 0.77 | METAP2 (0.62) | METAP2METAP1KMT2A | |
| Hydrochloric Acid SCHEMBL7359791 | 0.76 | METAP2 (0.67) | METAP2METAP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |