Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 12/20 | 0.63 |
| ▸ | METAP1 | P53582 | 8/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7352923 | 0.99 | METAP2 (0.62) | METAP2METAP1MEN1KMT2AF2RL1 | |
| SCHEMBL7354275 | 0.86 | METAP2 (0.63) | METAP2METAP1 | |
| SCHEMBL7358087 | 0.85 | METAP2 (0.60) | METAP2METAP1F2RL1 | |
| SCHEMBL7356908 | 0.84 | METAP2 (0.70) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7355712 | 0.83 | METAP2 (0.69) | METAP2METAP1 | |
| SCHEMBL7355425 | 0.82 | METAP2 (0.57) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7360183 | 0.81 | METAP2 (0.56) | METAP2METAP1 | |
| SCHEMBL6477759 | 0.81 | METAP2 (0.72) | METAP2METAP1KMT2A | |
| SCHEMBL6483172 | 0.78 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL7362084 | 0.78 | METAP2 (0.61) | METAP2METAP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |