Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.57 |
| ▸ | MME | P08473 | 8/20 | 0.54 |
| ▸ | ECE1 | P42892 | 8/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362203 | 1.00 | HRH4 (0.57) | HRH4MMEECE1CYP1A2CYP3A4 | |
| SCHEMBL7362207 | 1.00 | HRH4 (0.57) | HRH4MMEECE1CYP1A2CYP3A4 | |
| SCHEMBL7360715 | 0.95 | HRH4 (0.52) | HRH4MMEECE1CYP1A2CYP3A4 | |
| SCHEMBL7360720 | 0.95 | HRH4 (0.52) | HRH4MMEECE1CYP1A2CYP3A4 | |
| SCHEMBL7366217 | 0.88 | LTA4H (0.44) | HRH4MMEECE1ACEMEN1 | |
| SCHEMBL9069494 | 0.88 | ACE (0.61) | MMEECE1ACE | |
| SCHEMBL10792960 | 0.85 | LTA4H (0.46) | HRH4MMEECE1CYP3A4CYP2D6 | |
| SCHEMBL7363836 | 0.83 | HRH4 (0.53) | HRH4MMEECE1CYP1A2CYP3A4 | |
| SCHEMBL7363831 | 0.83 | HRH4 (0.53) | HRH4MMEECE1CYP1A2CYP3A4 | |
| SCHEMBL7363834 | 0.83 | HRH4 (0.53) | HRH4MMEECE1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |