Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | ECE1 | P42892 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362201 | 0.88 | HRH4 (0.57) | MMEHRH4ECE1ACEMEN1 | |
| SCHEMBL7362207 | 0.88 | HRH4 (0.57) | MMEHRH4ECE1ACEMEN1 | |
| SCHEMBL7362203 | 0.88 | HRH4 (0.57) | MMEHRH4ECE1ACEMEN1 | |
| SCHEMBL10790695 | 0.86 | MME (0.50) | MMEHRH4ECE1ACEMEN1 | |
| SCHEMBL7368050 | 0.86 | MME (0.50) | MMEHRH4ECE1ACEMEN1 | |
| SCHEMBL9069494 | 0.84 | ACE (0.61) | MMEECE1ACE | |
| SCHEMBL10792960 | 0.84 | LTA4H (0.46) | LTA4HMMEHRH4ECE1ACE | |
| SCHEMBL7360720 | 0.83 | HRH4 (0.52) | MMEHRH4ECE1MEN1KMT2A | |
| SCHEMBL7360715 | 0.83 | HRH4 (0.52) | MMEHRH4ECE1MEN1KMT2A | |
| SCHEMBL7316396 | 0.79 | MME (0.53) | MMEHRH4ECE1ACEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |