Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.63 |
| ▸ | PDE4A | P27815 | 8/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357911 | 0.89 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL18031245 | 0.88 | NPC1 (0.54) | PDE4DPDE4APDE4BPDE4CHSD17B10 | |
| SCHEMBL7363527 | 0.86 | C5AR1 (0.58) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1427488 | 0.82 | LMNA (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2587167 | 0.81 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2587166 | 0.81 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3245222 | 0.80 | SMPD1 (0.67) | HSD17B10 | |
| SCHEMBL28336430 | 0.80 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7356454 | 0.79 | PDE4D (0.74) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7362492 | 0.79 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |