Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362442 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 | |
| SCHEMBL7364525 | 0.81 | HSD17B10 (0.40) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 | |
| SCHEMBL7364529 | 0.81 | HSD17B10 (0.40) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 | |
| SCHEMBL7371751 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1GAAALOX5POLB | |
| SCHEMBL7371748 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1GAAALOX5POLB | |
| SCHEMBL9526095 | 0.73 | ALOX5 (0.36) | KDM4EALDH1A1GAAALOX5POLB | |
| SCHEMBL9526087 | 0.73 | ALOX5 (0.36) | KDM4EALDH1A1GAAALOX5POLB | |
| SCHEMBL11185360 | 0.73 | KDM4E (0.68) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 | |
| SCHEMBL11183546 | 0.70 | TDP1 (0.56) | KDM4EALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9754413 | 0.69 | PTGER3 (0.56) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |