Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.48 |
| ▸ | PDE4A | P27815 | 13/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269715 | 0.85 | PDE4B (0.49) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7355456 | 0.84 | PDE4A (0.51) | PDE4BPDE4APDE4DPDE4CPDE5A | |
| SCHEMBL8590945 | 0.84 | PDE4B (0.51) | PDE4BPDE4APDE4DPDE4CPDE5A | |
| SCHEMBL7394762 | 0.83 | PDE4B (0.58) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7765508 | 0.82 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7995009 | 0.82 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7914451 | 0.82 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7362566 | 0.82 | PDE4B (0.47) | PDE4BPDE4APDE4DPDE4CPDE5A | |
| SCHEMBL8192323 | 0.80 | PDE4B (0.47) | PDE4BPDE4APDE4DPDE4CPDE5A | |
| SCHEMBL7358676 | 0.80 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |