Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269715 | 0.89 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7845534 | 0.85 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7362931 | 0.84 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7358676 | 0.83 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL601637 | 0.83 | CASP1 (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6231255 | 0.82 | CASP1 (0.55) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6587626 | 0.82 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4DPOLB | |
| Ammonia Solution, Strong SCHEMBL7995011 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL6815488 | 0.81 | CASP1 (0.54) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL6826307 | 0.81 | CASP1 (0.54) | PDE4APDE4BPDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |