Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | PDE4A | P27815 | 5/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362892 | 0.92 | PDE4A (0.69) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7365917 | 0.91 | ALDH1A1 (0.70) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7366591 | 0.91 | ALDH1A1 (0.59) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7370523 | 0.88 | PDE4A (0.53) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7366074 | 0.87 | PDE4A (0.55) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7361626 | 0.86 | ALDH1A1 (0.56) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7362478 | 0.85 | PDE4A (0.77) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7370618 | 0.85 | RAB9A (0.51) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7365377 | 0.84 | PDE4A (0.54) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7367052 | 0.84 | F2RL3 (0.53) | ALDH1A1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |