Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359779 | 0.91 | MAPT (0.49) | MAPTPOLBMEN1KMT2AHPGD | |
| SCHEMBL7359782 | 0.91 | MAPT (0.49) | MAPTPOLBMEN1KMT2AHPGD | |
| SCHEMBL7487971 | 0.86 | MAPT (0.45) | MAPTPOLBMEN1KMT2AHPGD | |
| SCHEMBL7363299 | 0.86 | MAPT (0.45) | MAPTPOLBMEN1KMT2AHPGD | |
| SCHEMBL7367833 | 0.86 | EGFR (0.49) | MAPTPOLBMEN1KMT2AHPGD | |
| SCHEMBL7367827 | 0.86 | EGFR (0.49) | MAPTPOLBMEN1KMT2AHPGD | |
| SCHEMBL7358959 | 0.85 | TLR4 (0.48) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7367589 | 0.85 | MMP1 (0.45) | EGFR | |
| SCHEMBL7362930 | 0.83 | KMT2A (0.46) | MAPTPOLBMEN1KMT2AHPGD | |
| SCHEMBL7362935 | 0.83 | KMT2A (0.46) | MAPTPOLBMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024355-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |