Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.45 |
| ▸ | MMP2 | P08253 | 11/20 | 0.45 |
| ▸ | MMP9 | P14780 | 11/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363300 | 0.85 | MAPT (0.48) | EGFR | |
| SCHEMBL7364163 | 0.85 | JAK3 (0.48) | MMP1MMP2MMP9EGFRLTB4R | |
| SCHEMBL7364170 | 0.85 | JAK3 (0.48) | MMP1MMP2MMP9EGFRLTB4R | |
| SCHEMBL7486915 | 0.84 | LTB4R (0.41) | MMP1MMP2MMP9EGFRMAOB | |
| SCHEMBL7486921 | 0.84 | LTB4R (0.41) | MMP1MMP2MMP9EGFRMAOB | |
| SCHEMBL7367550 | 0.83 | CA12 (0.41) | KDM1AEGFR | |
| SCHEMBL7362038 | 0.81 | HDAC1 (0.46) | KDM1AEGFRLTB4RHDAC4MEF2D | |
| SCHEMBL7362037 | 0.81 | HDAC1 (0.46) | KDM1AEGFRLTB4RHDAC4MEF2D | |
| SCHEMBL6794751 | 0.78 | SIRT2 (0.49) | — | |
| SCHEMBL6794745 | 0.78 | SIRT2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024355-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |