Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364226 | 0.98 | TP53 (0.42) | DHODHNR4A2TP53MRGPRX1POLB | |
| SCHEMBL6092670 | 0.89 | DHODH (0.42) | DHODHNR4A2LMNAHTTKDM4E | |
| SCHEMBL7400116 | 0.89 | DHODH (0.47) | DHODHNR4A2POLBMAPT | |
| SCHEMBL6094311 | 0.88 | DHODH (0.43) | DHODHNR4A2TP53MAPTHTT | |
| SCHEMBL6095595 | 0.87 | DHODH (0.40) | DHODHNR4A2TP53HTTKDM4E | |
| SCHEMBL7363099 | 0.87 | DHODH (0.46) | DHODHNR4A2POLBLMNAMAPT | |
| SCHEMBL7359461 | 0.87 | DHODH (0.44) | DHODHNR4A2MEN1LMNAMAPT | |
| SCHEMBL6773568 | 0.85 | L3MBTL1 (0.41) | TP53MRGPRX1POLBL3MBTL1ATM | |
| SCHEMBL7397673 | 0.85 | POLB (0.40) | DHODHNR4A2TP53MRGPRX1POLB | |
| SCHEMBL6092550 | 0.85 | DHODH (0.39) | DHODHNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725775-B1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 1998-07-22 | — | — | EP | claimed |
| US-5484944-A | ANXIETY, SLEEP, MEMORY | NEUROGEN CORPORATION (US) | 1996-01-16 | — | — | US | claimed |
| US-5925770-A | GAMMA-AMINOBUTYRIC ACID DERIVATIVES FOR DIAGNOSIS OR TREATMENT OF ANXIETY, SLEEP DISORDERS, SEIZURES, OVERDOSES OF BENZODIAZEPINE TYPE DRUGS, COGNITION ACTIVATORS | NEUROGEN CORPORATION (US) | 1999-07-20 | — | — | US | disclosed |
| EP-0725775-B1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 1998-07-22 | — | — | EP | disclosed |
| US-5750702-A | Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1998002420-A9 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | — | 1998-04-23 | — | — | WO | disclosed |
| EP-0825193-A1 | Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands | NEUROGEN CORPORATION (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1998002420-A1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1998-01-22 | — | — | WO | disclosed |
| US-5608079-A | MEMORY ENHANCEMENT IN BRAINS | NEUROGEN CORPORATION (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0725775-A1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5484944-A | ANXIETY, SLEEP, MEMORY | NEUROGEN CORPORATION (US) | 1996-01-16 | — | — | US | disclosed |
| WO-1995011885-A1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1995-05-04 | — | — | WO | disclosed |