Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.57 |
| ▸ | MMP1 | P03956 | 16/20 | 0.57 |
| ▸ | MMP9 | P14780 | 16/20 | 0.57 |
| ▸ | MMP13 | P45452 | 16/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6759041 | 0.92 | ADAM17 (0.55) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL7043867 | 0.83 | ADAM17 (0.53) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL6568472 | 0.81 | MMP1 (0.82) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL6262676 | 0.81 | ADAM17 (0.84) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL6268284 | 0.78 | ADAM17 (0.72) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL6265234 | 0.77 | ADAM17 (0.84) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL6275563 | 0.76 | ADAM17 (0.85) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL6567493 | 0.75 | MMP1 (0.79) | ADAM17MMP1MMP9MMP13 | |
| Hydroxyamine SCHEMBL6704849 | 0.75 | ADAM17 (0.81) | ADAM17MMP1MMP9MMP13 | |
| Hydroxyamine SCHEMBL6702004 | 0.75 | ADAM17 (0.82) | ADAM17MMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044723-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS/TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |