Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.60 |
| ▸ | PDE4A | P27815 | 13/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.60 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474577 | 0.87 | PDE4D (0.67) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7425556 | 0.80 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7361164 | 0.78 | PDE4B (0.66) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7363664 | 0.78 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| Piclamilast SCHEMBL26573 | 0.76 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7417912 | 0.75 | PDE4D (0.69) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7335911 | 0.75 | PDE4D (0.98) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.74 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7439590 | 0.74 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7420334 | 0.74 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |