SCHEMBL7363726

SCHEMBL7363726

COC(=O)C=Cc1cn(CC(=O)N2CCCCC2Cc2ccccc2)c2ccc(C(=N)N)cc12

nearest known ligand 0.75

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
F2 P00734 7/20 0.75
PRSS1 P07477 3/20 0.75
PARP14 Q460N5 1/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.41
DAGLA Q9Y4D2 5/20 0.40
HCRTR1 O43613 1/20 0.40
HCRTR2 O43614 1/20 0.40
DAGLB Q8NCG7 2/20 0.39
USP2 O75604 1/20 0.38
DPP4 P27487 1/20 0.37
ALDH1A1 P00352 1/20 0.37
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7363721 1.00 F2 (0.75) F2PRSS1PARP14MEN1CYP1A2
SCHEMBL7367315 0.85 F2 (1.00) F2PRSS1MEN1KMT2AALDH1A1
SCHEMBL7367313 0.85 F2 (1.00) F2PRSS1MEN1KMT2AALDH1A1
SCHEMBL7359272 0.71 F2 (0.74) F2PRSS1MEN1KMT2AALDH1A1
SCHEMBL7359275 0.71 F2 (0.74) F2PRSS1MEN1KMT2AALDH1A1
SCHEMBL7434637 0.69 F2 (0.85) F2PRSS1MEN1KMT2AALDH1A1
SCHEMBL7396115 0.67 F2 (0.73) F2PRSS1MEN1KMT2AALDH1A1
SCHEMBL12466686 0.66 F2 (0.66) F2PRSS1
SCHEMBL8031092 0.65 F2 (1.00) F2PRSS1MEN1KMT2A
SCHEMBL8029406 0.65 F2 (0.72) F2PRSS1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0960102-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN Du Pont Pharmaceuticals Company (US) 1999-12-01 EP disclosed
WO-1998001428-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN DU PONT PHARMACEUTICALS COMPANY (US) 1998-01-15 WO disclosed