Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | TNF | P01375 | 10/20 | 0.53 |
| ▸ | PDE4A | P27815 | 5/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1370408 | 0.87 | GAA (0.55) | GAATNFPDE4APDE4BPDE4C | |
| SCHEMBL8358428 | 0.86 | GAA (0.50) | GAATNFPDE4APDE4BPDE4C | |
| SCHEMBL7363845 | 0.85 | PDE4A (0.61) | GAAPDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL11461220 | 0.85 | GAA (0.80) | GAATNFPDE4APDE4BPDE4C | |
| SCHEMBL6251186 | 0.82 | TNF (0.55) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2987068 | 0.82 | TNF (0.55) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5941271 | 0.82 | TNF (0.55) | TNFPDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL5743883 | 0.81 | TNF (0.54) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8771052 | 0.80 | TNF (0.56) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8903093 | 0.79 | GAA (0.46) | GAATNFALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584208-A4 | — | — | 1994-03-23 | — | — | EP | disclosed |
| EP-0584208-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992019594-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-11-12 | — | — | WO | disclosed |