Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 9/20 | 0.56 |
| ▸ | PDE4A | P27815 | 3/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770917 | 0.86 | ACHE (0.48) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8771284 | 0.85 | ACHE (0.56) | TNFPPARGPPARDPPARAACHE | |
| SCHEMBL8770891 | 0.85 | MTNR1A (0.50) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6251186 | 0.83 | TNF (0.55) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5941271 | 0.83 | TNF (0.55) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2987068 | 0.83 | TNF (0.55) | TNFPDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL5743883 | 0.81 | TNF (0.54) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7363752 | 0.80 | GAA (0.59) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17997742 | 0.80 | TSHR (0.50) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL10335590 | 0.79 | PPARG (0.61) | PDE4APDE4BPDE4CPDE4DPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3292891-A | — | — | None | — | — | JP | disclosed |
| EP-0451668-B1 | Process for the production of optically active alkyl 3-aryl-3-hydroxypropionates | CHISSO CORP (JP) | 1997-08-13 | — | — | EP | disclosed |
| US-5202457-A | Enzyme catalyzed transesterification, resolution of optical active alkyl 3-aryl-3-hydroxypropionate | CHISSO CORPORATION (JP) | 1993-04-13 | — | — | US | disclosed |
| JP-H03292891-A | OPTICALLY ACTIVE 3-ARYL-3-HYDROXYPROPIONIC ACID ALKYL ESTER | CHISSO CORP | 1991-12-24 | — | — | JP | disclosed |
| EP-0451668-A2 | Optically active alkyl 3-aryl-3-hydroxypropionates and a method for producing thereof | CHISSO CORPORATION (JP) | 1991-10-16 | — | — | EP | disclosed |