Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9001234 | 0.72 | GAA (0.39) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7729617 | 0.72 | GAA (0.39) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7368463 | 0.72 | LMNA (0.41) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL36264 | 0.72 | GAA (0.44) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| Water SCHEMBL2573342 | 0.70 | GAA (0.42) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| Lithium Ion SCHEMBL15773054 | 0.70 | GAA (0.37) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL15772816 | 0.70 | GAA (0.37) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1239169 | 0.70 | GAA (0.42) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL16140246 | 0.70 | GAA (0.37) | GAAGRIN2DGRIN3BGRIN1GRIN2A | |
| Potassium Ion SCHEMBL1239168 | 0.70 | GAA (0.37) | GAAGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5907068-A | TRIFLUOROMETHYLSUBSTITUTED COMPOUND INCLUDED IN PEPTIDES | ZENECA INC. (US) | 1999-05-25 | — | — | US | disclosed |
| US-5726158-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE USEFUL IN TREATING TISSUE DEGENERATIVE DISEASES; TRIFLUOROMETHYL KETONE SUBSTITUTED DI-, TRI-, AND TETRA-PEPTIDE DERIVATIVES | ZENECA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5414132-A | Peptide intermediates | ZENECA INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5194588-A | Inhibitors of human leukocyte elastase, di-, tri- and tetra-peptides | ICI AMERICAS INC. (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0189305-B1 | PEPTIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1992-07-29 | — | — | EP | disclosed |
| US-5055450-A | Di-, tri- and tetrapeptides as inhibitors of human leukocyte elastase | ICI AMERICAS INC. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4923890-A | Difluoro keto compounds and their use as HLE inhibitors | ICI AMERICAS INC. (US) | 1990-05-08 | — | — | US | disclosed |
| US-4910190-A | Containing a nitrogen containing heterocycle ring structure | ICI AMERICAS INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4880780-A | RESPIRATORY SYSTEM DISORDERS | ICI AMERICAS INC. (US) | 1989-11-14 | — | — | US | disclosed |
| US-4873221-A | Difluoro peptide compounds | ICI AMERICAS INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0249349-A1 | Difluoroketo compounds | ICI AMERICAS INC. (US) | 1987-12-16 | — | — | EP | disclosed |
| EP-0248562-A2 | Difluoro peptide compounds | ZENECA INC. (US) | 1987-12-09 | — | — | EP | disclosed |
| EP-0204571-A2 | Selected difluoro derivatives | ICI AMERICAS INC. (US) | 1986-12-10 | — | — | EP | disclosed |