Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.63 |
| ▸ | FCER2 | P06734 | 5/20 | 0.63 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 4/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | MMP7 | P09237 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8749878 | 0.92 | MMP1 (0.57) | MMP1FCER2ADAM17MMP2MMP9 | |
| SCHEMBL7365448 | 0.86 | MMP1 (0.55) | MMP1FCER2ADAM17MMP2MMP9 | |
| SCHEMBL6412867 | 0.82 | MMP3 (0.51) | MMP1FCER2ADAM17MMP2MMP9 | |
| SCHEMBL7391172 | 0.82 | MMP1 (0.47) | MMP1FCER2ADAM17MMP2MMP9 | |
| SCHEMBL7365016 | 0.79 | FCER2 (0.45) | MMP1FCER2ADAM17MMP2MMP9 | |
| SCHEMBL6415490 | 0.79 | MMP1 (0.47) | MMP1FCER2ADAM17MMP2MMP9 | |
| SCHEMBL7355612 | 0.79 | MMP1 (0.42) | MMP1FCER2ADAM17MMP2MMP8 | |
| SCHEMBL7356209 | 0.78 | MMP1 (0.49) | MMP1FCER2ADAM17MMP2MMP9 | |
| SCHEMBL6416122 | 0.78 | MMP1 (0.47) | MMP1FCER2ADAM17MMP2MMP9 | |
| SCHEMBL7360187 | 0.77 | MMP1 (0.40) | MMP1FCER2ADAM17MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691382-A | ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0667770-B1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARM (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0667770-A1 | INHIBITION OF TNF PRODUCTION. | BRITISH BIOTECH PHARM (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010990-A1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-05-26 | — | — | WO | disclosed |