Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.56 |
| ▸ | PDE4A | P27815 | 8/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332617 | 0.88 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7329994 | 0.85 | POLB (0.55) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL16327026 | 0.84 | ALDH1A1 (0.51) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL2371289 | 0.84 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL908271 | 0.84 | ABL1 (0.59) | MEN1ALDH1A1KMT2AATM | |
| SCHEMBL7023339 | 0.83 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL6366896 | 0.83 | RECQL (0.60) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL7483310 | 0.83 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7340266 | 0.81 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7422501 | 0.80 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |