Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308698 | 0.86 | PDE4A (0.57) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7369665 | 0.83 | PDE4A (0.53) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL7365389 | 0.80 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL7365393 | 0.80 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL6636364 | 0.75 | PDE4A (0.71) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL7360388 | 0.74 | PDE4D (0.66) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL7369668 | 0.74 | PDE4A (0.56) | PDE4APDE4DPDE4CPDE4BCFTR | |
| SCHEMBL7359713 | 0.72 | PDE4A (0.75) | PDE4APDE4DPDE4CPDE4BCFTR | |
| SCHEMBL7361971 | 0.72 | PDE4A (0.60) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL7362755 | 0.72 | PDE4A (0.60) | PDE4APDE4DPDE4CPDE4BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |