Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | USP5 | P45974 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11757895 | 0.83 | SRD5A2 (0.61) | CYP1A2SMN1; SMN2FFAR1LMNARAB9A | |
| SCHEMBL11758021 | 0.83 | SMN1; SMN2 (0.67) | CYP1A2SMN1; SMN2FFAR1LMNARAB9A | |
| SCHEMBL7441533 | 0.81 | CYP1A2 (0.60) | CYP1A2SMN1; SMN2FFAR1LMNARAB9A | |
| SCHEMBL11762828 | 0.81 | RAB9A (0.51) | CYP1A2SMN1; SMN2FFAR1LMNARAB9A | |
| SCHEMBL2044221 | 0.80 | SRD5A2 (0.60) | ALDH1A1CSNK2A1SRD5A2TSHRPRKAG1 | |
| SCHEMBL29140064 | 0.80 | SRD5A2 (0.60) | SMN1; SMN2LMNAALDH1A1CSNK2A1KMT2A | |
| SCHEMBL727064 | 0.80 | TSHR (0.59) | CYP1A2SMN1; SMN2FFAR1LMNARAB9A | |
| SCHEMBL6175390 | 0.79 | CYP1A2 (0.57) | CYP1A2SMN1; SMN2FFAR1LMNARAB9A | |
| SCHEMBL6207095 | 0.78 | SRD5A2 (0.50) | LMNAALDH1A1CSNK2A1KMT2ASRD5A2 | |
| SCHEMBL7367792 | 0.77 | MAPT (0.55) | SMN1; SMN2LMNARAB9AALDH1A1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028716-A1 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1998025597-A2 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 1998-06-18 | — | — | WO | disclosed |
| US-4021479-A | ANTIPHLOGISTICS AND ANTIPROLIFERATIVES | BOEHRINGER INGELHEIM GMBH (DT) | 1977-05-03 | — | — | US | disclosed |