Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | S100A4 | P26447 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11585221 | 0.89 | HSD17B1 (0.54) | MAPTSMN1; SMN2S100A4SRD5A2ALDH1A1 | |
| SCHEMBL29140064 | 0.85 | SRD5A2 (0.60) | MAPTSMN1; SMN2SRD5A2ALDH1A1KDM4E | |
| SCHEMBL2044221 | 0.85 | SRD5A2 (0.60) | SRD5A2ALDH1A1CSNK2A1PRKAB2PRKAG1 | |
| SCHEMBL6207095 | 0.84 | SRD5A2 (0.50) | SRD5A2ALDH1A1KDM4EL3MBTL1CSNK2A1 | |
| SCHEMBL25598320 | 0.83 | CNR2 (0.51) | MAPTS100A4ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL14176467 | 0.83 | MAPT (0.61) | MAPTSMN1; SMN2S100A4ALDH1A1KDM4E | |
| SCHEMBL6139775 | 0.83 | PTGS1 (0.51) | MAPTSMN1; SMN2S100A4SRD5A2ALDH1A1 | |
| SCHEMBL11801781 | 0.82 | SRD5A2 (0.43) | MAPTSMN1; SMN2SRD5A2ALDH1A1KDM4E | |
| SCHEMBL11801774 | 0.82 | SRD5A2 (0.43) | MAPTSMN1; SMN2SRD5A2ALDH1A1KDM4E | |
| SCHEMBL11801787 | 0.82 | SRD5A2 (0.43) | MAPTSMN1; SMN2SRD5A2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344464-B1 | Use of tetrahydropyridine derivatives to prepare medicines for treating diseases causing demyelination | SANOFI-SYNTHELABO (FR) | 2002-02-05 | — | — | US | disclosed |
| US-6342505-B1 | inhibiting apoptosis using xaliproden hydrochloride, or other tetrahydropyridine derivatives | SANOFI-SYNTHELABO (FR) | 2002-01-29 | — | — | US | disclosed |
| US-4301313-A | ANTIINFLAMMATORY AGENTS, ANTIPYRETICS, ANALGESICS | ELI-LILLY AND COMPANY (US) | 1981-11-17 | — | — | US | disclosed |
| US-4267388-A | BY SULFONATING A BENZYL ALCOHOL COMPOUND, REDUCING THE SULFONYL DERIVATIVE TO A HALOSTYRENYL COMPOUND, AND DEHYDROHALOGENATING TO THE ETHYNYLBENZENE | WILLIAM H. RORER, INC. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4226887-A | P-BIPHENYLYLACETYLENE | ELI LILLY AND COMPANY (US) | 1980-10-07 | — | — | US | disclosed |
| US-3991212-A | PHENYLACETYLENE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1976-11-09 | — | — | US | disclosed |
| US-3968251-A | Arylacetylene compounds as antithrombotic agents | ELI LILLY AND COMPANY (US) | 1976-07-06 | — | — | US | disclosed |
| US-3950427-A | ANTIINFLAMMATORY, ANTIPYRETIC | BOEHRINGER INGELHEIM GMBH (DT) | 1976-04-13 | — | — | US | disclosed |
| US-3939278-A | Phenoxyphenyl-acetylenes and thio analogues thereof as antithrombotic agents | ELI LILLY AND COMPANY (US) | 1976-02-17 | — | — | US | disclosed |