Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | LAP3 | P28838 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364336 | 1.00 | POLB (0.53) | POLBGAAMMP8CYP1A2SMN1; SMN2 | |
| SCHEMBL4116935 | 1.00 | POLB (0.53) | POLBGAAMMP8CYP1A2SMN1; SMN2 | |
| SCHEMBL1239980 | 0.89 | POLB (0.52) | POLBGAAMMP8SMN1; SMN2MEN1 | |
| SCHEMBL7411085 | 0.86 | KMT2A (0.47) | POLBGAAMEN1KMT2ANPSR1 | |
| SCHEMBL7376210 | 0.85 | TSHR (0.53) | CYP1A2SRRALPIPKMPTGS1 | |
| SCHEMBL7376215 | 0.85 | TSHR (0.53) | CYP1A2SRRALPIPKMPTGS1 | |
| SCHEMBL11129434 | 0.85 | LDHA (0.58) | GAAPPARGPPARA | |
| SCHEMBL11310007 | 0.84 | POLB (0.50) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7382332 | 0.84 | MMP8 (0.44) | POLBGAAMMP8CYP1A2SMN1; SMN2 | |
| SCHEMBL4835745 | 0.84 | POLB (0.50) | POLBGAASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |