Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.50 |
| ▸ | F2 | P00734 | 6/20 | 0.50 |
| ▸ | F7 | P08709 | 3/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.47 |
| ▸ | PLAU | P00749 | 4/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.47 |
| ▸ | PLG | P00747 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.46 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 2/20 | 0.43 |
| ▸ | F9 | P00740 | 1/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434169 | 0.86 | F10 (0.48) | F10F2F7PRSS1PLAU | |
| SCHEMBL7361502 | 0.81 | F10 (0.61) | F10F2F7PRSS1PLAU | |
| SCHEMBL7362340 | 0.79 | F10 (0.58) | F10F2F7PRSS1PLAU | |
| SCHEMBL7361483 | 0.76 | F10 (0.57) | F10F2F7PRSS1PLAU | |
| SCHEMBL7364424 | 0.76 | F10 (0.68) | F10F2PRSS1 | |
| SCHEMBL8031089 | 0.76 | F10 (0.65) | F10F2F7PRSS1PLAU | |
| SCHEMBL7365504 | 0.75 | F10 (0.47) | F10F2F7PRSS1PLAU | |
| SCHEMBL7366854 | 0.75 | F10 (0.55) | F10F2F7PRSS1PLAU | |
| SCHEMBL8029320 | 0.73 | RAB9A (0.53) | F10F2F7PRSS1PLAU | |
| SCHEMBL29354281 | 0.68 | F10 (1.00) | F10F2F7PRSS1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043257-A | ANTICOAGULANT; PYRIDINE SUBSTITUTED INDAZOLE COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |