Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20303521 | 0.87 | MAPT (0.44) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL15778596 | 0.87 | KDM2B (0.45) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL18783666 | 0.83 | MAPT (0.41) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7362050 | 0.83 | CCR5 (0.47) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7369381 | 0.82 | CCR5 (0.46) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7335722 | 0.81 | MAPT (0.52) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20303397 | 0.81 | MAPT (0.39) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL25370095 | 0.80 | PTGDR2 (0.58) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20303535 | 0.80 | PTGDR (0.46) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4477210 | 0.79 | MAPT (0.53) | MAPTMEN1KMT2AUSP2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |