Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18783666 | 0.87 | MAPT (0.41) | MAPTMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL20303521 | 0.84 | MAPT (0.44) | MAPTMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL7364503 | 0.81 | MAPT (0.58) | MAPTMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL7362050 | 0.81 | CCR5 (0.47) | MAPTMEN1KMT2AL3MBTL1KDM4E | |
| Hydrochloric Acid SCHEMBL7369381 | 0.79 | CCR5 (0.46) | MAPTMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL6297379 | 0.78 | SLC6A4 (0.45) | MAPTHSP90AA1HTR2ASLC6A4 | |
| SCHEMBL20303535 | 0.77 | PTGDR (0.46) | MAPTMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL263191 | 0.77 | L3MBTL1 (0.52) | MAPTMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL22000046 | 0.76 | TDP1 (0.51) | MAPTMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL7335722 | 0.76 | MAPT (0.52) | MAPTMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558298-A1 | ANTIDIABETIC SPIROCHROMAN COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018118670-A1 | ANTIDIABETIC SPIROCHROMAN COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |