Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362761 | 0.92 | MAPT (0.61) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7364096 | 0.90 | MAPT (0.53) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7361400 | 0.82 | CLK4 (0.62) | MAPTSMN1; SMN2HTR6KDM4EALDH1A1 | |
| SCHEMBL7364155 | 0.82 | KDM4E (0.53) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7362060 | 0.79 | KDM4E (0.45) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7362717 | 0.77 | TLR8 (0.55) | MAPTSMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL7360098 | 0.76 | MAP2K1 (0.56) | MAPTSMN1; SMN2KDM4EALDH1A1MAP2K1 | |
| SCHEMBL7366580 | 0.75 | MAP2K1 (0.55) | MAPTSMN1; SMN2KDM4EALDH1A1MAP2K1 | |
| SCHEMBL19455732 | 0.75 | ALDH1A1 (0.48) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL19455697 | 0.75 | ALDH1A1 (0.48) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |