Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexane SCHEMBL17156204 | 0.91 | EPHX1 (0.41) | SHBGEPHX1TP53KDM4EGMNN | |
| SCHEMBL27732506 | 0.91 | EPHX1 (0.41) | SHBGEPHX1TP53KDM4EGMNN | |
| Cyclohexane SCHEMBL6475300 | 0.91 | EPHX1 (0.41) | SHBGEPHX1TP53KDM4EGMNN | |
| Cyclohexane SCHEMBL6482192 | 0.91 | EPHX1 (0.41) | SHBGEPHX1TP53KDM4EGMNN | |
| SCHEMBL185455 | 0.91 | — | — | |
| Cyclohexane SCHEMBL3485509 | 0.91 | EPHX1 (0.41) | SHBGEPHX1TP53KDM4EGMNN | |
| Cyclohexane SCHEMBL2022364 | 0.91 | EPHX1 (0.41) | SHBGEPHX1TP53KDM4EGMNN | |
| Cyclohexane SCHEMBL2027488 | 0.91 | EPHX1 (0.41) | SHBGEPHX1TP53KDM4EGMNN | |
| SCHEMBL16933771 | 0.87 | — | — | |
| SCHEMBL6845253 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714658-B1 | NOVEL HYBRID CHOLINESTERASE INHIBITORS | UNIV WARSZAWSKI (PL) | 2015-04-29 | — | — | EP | disclosed |
| US-8841453-B2 | Hybrid cholinesterase inhibitors | UNIWERSYTET WARSZAWSKI (PL) | 2014-09-23 | — | — | US | disclosed |
| US-20140080860-A1 | NOVEL HYBRID CHOLINESTERASE INHIBITORS | CENTRUM MEDYCZNE KSZTALCENIA PODYPLOMOWEGO (PL) | 2014-03-20 | — | — | US | disclosed |
| WO-2012165981-A1 | NOVEL HYBRID CHOLINESTERASE INHIBITORS | UNIWERSYTET WARSZAWSKI (PL) | 2012-12-06 | — | — | WO | disclosed |
| US-5827849-A | HAVING INHIBITORY EFFECT ON INFLAMMATION AND BONE DEGRADATION, ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASIS-INHIBITING EFFECT | KARL THOMAE GMBH (DE) | 1998-10-27 | — | — | US | disclosed |
| WO-1997048702-A1 | BENZAZEPINE DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-12-24 | — | — | WO | disclosed |
| US-4647560-A | COGNITION ACTIVATORS | TROPONWERKE GMBH & CO. KG (DE) | 1987-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080860-A1 | NOVEL HYBRID CHOLINESTERASE INHIBITORS | BCHE, ACHE, HNMT | SHBG 1290/4885EPHX1 280/4885TP53 2307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.