Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 15/20 | 0.83 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.77 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.77 |
| ▸ | HTR3B | O95264 | 1/20 | 0.77 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.77 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.77 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.77 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.77 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.77 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497547 | 1.00 | HTR3A (0.83) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL17163591 | 0.91 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL17163592 | 0.91 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL17163635 | 0.90 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL17163632 | 0.90 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL7439485 | 0.89 | HTR3A (0.68) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL7430281 | 0.89 | HTR3A (0.68) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Hydrochloric Acid SCHEMBL7293807 | 0.88 | HTR3A (0.70) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Hydrochloric Acid SCHEMBL7293813 | 0.88 | HTR3A (0.70) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL34178 | 0.87 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498466-B1 | Indazole-3-carboxamide and -3-carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 2002-07-24 | — | — | EP | claimed |
| EP-0200444-A2 | Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity | BEECHAM GROUP PLC (GB) | 1986-11-05 | — | — | EP | claimed |
| EP-0498466-B1 | Indazole-3-carboxamide and -3-carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 2002-07-24 | — | — | EP | disclosed |
| US-5034398-A | Analgesics | BEECHAM GROUP P.L.C. (GB) | 1991-07-23 | — | — | US | disclosed |
| US-4886808-A | Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis | BEECHAM GROUP P.L.C. (GB) | 1989-12-12 | — | — | US | disclosed |