SCHEMBL7364745

SCHEMBL7364745

CC1CN(C(=O)OC(C)(C)C)CCN1c1ccc(O)cc1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMARCA2 P51531 1/20 0.52
SMARCA4 P51532 1/20 0.52
PBRM1 Q86U86 1/20 0.52
GPR119 Q8TDV5 13/20 0.52
LMNA P02545 2/20 0.45
ESR2 Q92731 1/20 0.45
TP53 P04637 1/20 0.45
THRB P10828 1/20 0.45
ADAMTS5 Q9UNA0 1/20 0.44
SETD7 Q8WTS6 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPT P10636 1/20 0.44
ABCB1 P08183 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15442285 1.00 SMARCA2 (0.52) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL13279217 1.00 SMARCA2 (0.52) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL652991 0.88 MEN1 (0.53) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL652990 0.88 MEN1 (0.53) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL1409835 0.88 SMARCA2 (0.53) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL656085 0.88 MEN1 (0.53) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL1409607 0.88 SMARCA2 (0.53) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL1409606 0.88 SMARCA2 (0.53) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL15858050 0.88 GPR119 (0.48) SMARCA2SMARCA4PBRM1GPR119ADAMTS5
SCHEMBL31112041 0.88 GPR119 (0.48) SMARCA2SMARCA4PBRM1GPR119LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2697232-B1 6,7-DIHYDROIMIDAZO[2,1-B][1,3]OXAZINE BACTERICIDES OTSUKA PHARMA CO LTD (JP) 2016-05-18 EP disclosed
US-9051333-B2 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2015-06-09 US disclosed
US-20140031342-A1 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2014-01-30 US disclosed
US-5994356-A ANTICOAGULANT KARL THOMAE (DE) 1999-11-30 US disclosed
EP-0892783-A1 CARBOXYLIC ACID DERIVATIVES WITH AN AGGREGATION-INHIBITING ACTION Dr. Karl Thomae GmbH (DE) 1999-01-27 EP disclosed
WO-1997037975-A1 CARBOXYLIC ACID DERIVATIVES WITH AN AGGREGATION-INHIBITING ACTION DR. KARL THOMAE GMBH (DE) 1997-10-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140031342-A1 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES BRD1, OXA1L, QDPR SMARCA2 3763/4885SMARCA4 3880/4885PBRM1 489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.