SCHEMBL7364773

SCHEMBL7364773

CC(C)(C)OC(=O)C1CNc2cc(C(C)(C)C)c(S)cc21

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.33
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7356234 0.79 EPHX2 (0.30) EPHX2
SCHEMBL7357650 0.76 EPHX2 (0.37) EPHX2MAPK1
SCHEMBL1161006 0.75 EPHX2 (0.38) EPHX2MAPK1
SCHEMBL4586631 0.74 EPHX2 (0.37) EPHX2MAPK1
SCHEMBL3986151 0.74 EPHX2 (0.37) EPHX2
SCHEMBL7361919 0.73 CASP3 (0.33)
SCHEMBL5576688 0.72 EPHX2 (0.49) EPHX2MAPK1
SCHEMBL27824398 0.72 EPHX2 (0.36) EPHX2MAPK1
SCHEMBL6810224 0.70 AR (0.41)
SCHEMBL5763199 0.69 GABRA1 (0.37) EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1112269-A2 HIV PROTEASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-07-04 EP disclosed
WO-2000015634-A2 HIV PROTEASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2000-03-23 WO disclosed