Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | PEPD | P12955 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364577 | 0.79 | GRM2 (0.41) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7443453 | 0.73 | SLC1A2 (0.44) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL5053182 | 0.73 | SLC1A2 (0.47) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7399439 | 0.71 | SLC1A2 (0.46) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7364671 | 0.70 | SLC1A2 (0.44) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL5052996 | 0.70 | SLC1A2 (0.44) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7397702 | 0.69 | SLC1A2 (0.43) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7360984 | 0.69 | GPR84 (0.43) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7392222 | 0.69 | SLC1A2 (0.43) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7357839 | 0.69 | SLC1A2 (0.50) | SLC1A2CYP2C9CYP2C19GRM8GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889001-A | TREATING CONDITIONS WHERE DECREASED VASOPRESSIN LEVELS ARE DESIRED AND DISEASES WITH EXCESS RENAL WATER REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5854237-A | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-12-29 | — | — | US | disclosed |
| US-5843944-A | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5736540-A | CONGESTIVE HEART FAILURE | AMERICAN CYANAMID COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| US-5733905-A | CONGESTIVE HEART FAILURE; KIDNEY DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |