Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 4/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392222 | 0.89 | SLC1A2 (0.43) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL7364671 | 0.80 | SLC1A2 (0.44) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL5053182 | 0.79 | SLC1A2 (0.47) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL7360984 | 0.79 | GPR84 (0.43) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL7357839 | 0.79 | SLC1A2 (0.50) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL5052996 | 0.76 | SLC1A2 (0.44) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL7361069 | 0.75 | CYP1A2 (0.45) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL5051242 | 0.74 | FOLH1 (0.44) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL7745751 | 0.73 | GRM8 (0.38) | SLC1A2GRM2GRM3CYP2C9CYP2C19 | |
| SCHEMBL7364577 | 0.73 | GRM2 (0.41) | SLC1A2GRM2GRM3CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |