Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.57 |
| ▸ | PDE4A | P27815 | 12/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919796 | 0.84 | PDE4B (0.61) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL7144760 | 0.83 | PDE4B (0.55) | PDE4BPDE4APDE4DPDE4CSLC6A4 | |
| SCHEMBL6587617 | 0.81 | PDE4B (0.58) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL5610531 | 0.81 | PDE4A (0.59) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL6586771 | 0.80 | PDE4B (0.50) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL8203861 | 0.79 | PDE4B (0.54) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL4728355 | 0.78 | PDE4B (0.56) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL7353885 | 0.78 | PDE4D (0.71) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL7362909 | 0.77 | PDE4B (0.50) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL4727275 | 0.77 | PDE4B (0.55) | PDE4BPDE4APDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459145-A | Calcium independent camp phosphodiesterase inhibitor antidepressant | PFIZER INC. (US) | 1995-10-17 | — | — | US | disclosed |
| US-5294730-A | A-Amino-4-alkoxy-3-polycycloalkyloxybenzyl cyanide derivatives | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0247725-B1 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |
| US-5196426-A | CALCIUM INDEPENDENT C AMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5128358-A | Aryl substituted nitrogen heterocyclic antidepressants | PFIZER INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0247725-A2 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER INC. (US) | 1987-12-02 | — | — | EP | disclosed |
| WO-1987006576-A1 | CALCIUM INDEPENDENT CAMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1987-11-05 | — | — | WO | disclosed |