Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 6/20 | 0.45 |
| ▸ | PLG | P00747 | 4/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 5/20 | 0.35 |
| ▸ | MMP12 | P39900 | 3/20 | 0.33 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7376136 | 0.94 | PLAU (0.48) | PLAUPLGADAMTS4PLATMMP13 | |
| Trifluoroacetic Acid SCHEMBL7456725 | 0.91 | PLG (0.47) | PLAUPLGADAMTS4PLATMMP13 | |
| SCHEMBL6437440 | 0.86 | PLAU (0.40) | PLAUPLGPLATF2 | |
| Trifluoroacetic Acid SCHEMBL7368831 | 0.85 | F2 (0.46) | ADAMTS4MMP13MMP1MMP2MMP3 | |
| Trifluoroacetic Acid SCHEMBL7372457 | 0.85 | MMP9 (0.45) | ADAMTS4MMP13MMP2MMP7MMP9 | |
| Hydrochloric Acid SCHEMBL7588548 | 0.84 | PLG (0.50) | PLAUPLGADAMTS4PLATMMP13 | |
| SCHEMBL6434837 | 0.84 | PLAU (0.37) | PLAUPLGPLAT | |
| Trifluoroacetic Acid SCHEMBL7369183 | 0.84 | PLAU (0.43) | PLAUF2TMPRSS6 | |
| Trifluoroacetic Acid SCHEMBL7374048 | 0.82 | PLAU (0.45) | PLAUF2TMPRSS6NPSR1 | |
| SCHEMBL6434174 | 0.81 | PLAU (0.50) | PLAUPLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |