Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 11/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7374048 | 0.91 | PLAU (0.45) | PLAUF2TMPRSS6KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7365054 | 0.84 | PLAU (0.45) | PLAUF2TMPRSS6 | |
| Hydrochloric Acid SCHEMBL6433670 | 0.83 | PLAU (0.51) | PLAUF2KMT2A | |
| Trifluoroacetic Acid SCHEMBL6432736 | 0.83 | PLAU (0.46) | PLAUKDM4EALDH1A1KMT2A | |
| SCHEMBL6965041 | 0.83 | F2 (0.35) | PLAUF2TMPRSS6KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7456725 | 0.82 | PLG (0.47) | PLAU | |
| Trifluoroacetic Acid SCHEMBL7368831 | 0.82 | F2 (0.46) | F2TMPRSS6ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7372457 | 0.82 | MMP9 (0.45) | F2TMPRSS6 | |
| Hydrochloric Acid SCHEMBL6432755 | 0.82 | F2 (0.35) | PLAUF2TMPRSS6KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7372144 | 0.81 | CA1 (0.36) | F2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |