Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 10/20 | 0.50 |
| ▸ | MMP1 | P03956 | 9/20 | 0.49 |
| ▸ | MMP2 | P08253 | 6/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | MMP8 | P22894 | 5/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8156824 | 0.92 | MMP3 (0.53) | MMP3MMP1MMP2PPARAPPARG | |
| SCHEMBL7361337 | 0.89 | MMP3 (0.64) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7361333 | 0.89 | MMP3 (0.64) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7365921 | 0.88 | CTSK (0.59) | MMP3MMP1MMP2CTSBCTSK | |
| SCHEMBL7364811 | 0.88 | CTSK (0.59) | MMP3MMP1MMP2CTSBCTSK | |
| SCHEMBL6968687 | 0.88 | MMP3 (0.56) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL6968692 | 0.88 | MMP3 (0.56) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7357736 | 0.87 | MMP3 (0.65) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7363971 | 0.86 | CTSK (0.56) | MMP3MMP1MMP2CTSBCTSK | |
| SCHEMBL7363967 | 0.86 | CTSK (0.56) | MMP3MMP1MMP2CTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025949-A1 | SUBSTITUTED 5-AMINO-1,3,4-THIADIAZOLE-2-THIONES | PROSCRIPT, INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0845002-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1998-06-03 | — | — | EP | disclosed |
| WO-1996040745-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1996-12-19 | — | — | WO | disclosed |