Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 13/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | TACR3 | P29371 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364712 | 0.90 | F2 (0.64) | F2TP53HSD17B10GRIN2DGRIN3B | |
| SCHEMBL8158003 | 0.84 | GRIN2D (0.73) | F2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7368689 | 0.83 | F2 (0.60) | F2TP53HSD17B10GRIN1GRIN2B | |
| SCHEMBL7370469 | 0.82 | TP53 (0.59) | TP53HSD17B10GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7365964 | 0.80 | TACR3 (0.63) | F2TP53HSD17B10GRIN2BPRSS1 | |
| SCHEMBL7365097 | 0.76 | F2 (1.00) | F2PRSS1F10 | |
| SCHEMBL7365961 | 0.74 | MEN1 (0.69) | F2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7362115 | 0.74 | F2 (0.82) | F2PRSS1F10 | |
| SCHEMBL5203581 | 0.74 | GAA (0.54) | TP53GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23682656 | 0.72 | TACR3 (0.83) | TP53HSD17B10MEN1KMT2ATACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |