Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 2/20 | 0.63 |
| ▸ | TACR1 | P25103 | 1/20 | 0.63 |
| ▸ | F2 | P00734 | 11/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363982 | 0.85 | LMNA (0.59) | TACR3TACR1F2PRSS1MEN1 | |
| SCHEMBL7365266 | 0.82 | HTR1A (0.55) | F2PRSS1MEN1KMT2AF10 | |
| SCHEMBL7367810 | 0.81 | RAB9A (0.48) | TACR3TACR1F2PRSS1F10 | |
| SCHEMBL15155707 | 0.80 | F2 (0.51) | F2PRSS1MEN1KMT2AF10 | |
| SCHEMBL7365098 | 0.80 | F2 (0.61) | TACR3F2PRSS1MEN1KMT2A | |
| SCHEMBL7368689 | 0.79 | F2 (0.60) | F2PRSS1MEN1KMT2AF10 | |
| SCHEMBL3815254 | 0.79 | MEN1 (0.60) | TACR3TACR1F2PRSS1MEN1 | |
| SCHEMBL6918215 | 0.76 | MEN1 (0.55) | TACR3TACR1MEN1KMT2A | |
| SCHEMBL7368234 | 0.76 | SIGMAR1 (0.74) | PRSS1F10 | |
| SCHEMBL6272376 | 0.76 | MEN1 (0.57) | TACR3TACR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | claimed |
| US-6043257-A | ANTICOAGULANT; PYRIDINE SUBSTITUTED INDAZOLE COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5886191-A | ANTICOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-03-23 | — | — | US | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |